Thymidine phosphorylase (TP) contributes in the promotion of an angiogenic activity and identical to platelet derived endothelial cell growth factor (PD-ECGF). Large production of TP is found in several tumors and contributes a vital part in the development of angiogenesis, progression of tumor, incursion and metastasis. The balanced enzymatic activity of thymidine phosphorylase is vital to induce beneficial angiogenesis. Factors responsible for tumor growth stimulate undesired proangiogenic activity and become unable to maintain tight equilibrium between proangiogenic and antiangiogenic activity. The end product of degraded thymidine phosphorylase is 2-deoxy-D-ribose. This monosaccharide (2-deoxy-D-ribose) is believed to stimulate unwished angiogenesis, migration of abnormal cells, increase in tumor size and metastasis. At the moment, we believe that there is considerable space for the development of potent angiogenesis inhibitors and TP inhibitor because they may act as next generation promising anticancer agents.